abstract：:Embryonic spinal cord motor neurons (MNs) can be maintained in vitro for weeks with a cocktail of trophic factors and muscle-derived factors under serum-containing conditions. Here we investigated the beneficial effects of muscle-derived factors in the form of muscle-conditioned medium (MCM) on the survival and neurit...

journal_title：Experimental neurology

authors： Montoya G JV,Sutachan JJ,Chan WS,Sideris A,Blanck TJ,Recio-Pinto E

更新日期：2009-12-01 00:00:00

abstract：:Macrophage colony stimulating factor (M-CSF) is a cytokine that regulates the survival, proliferation and maturation of microglial cells. Administration of M-CSF can promote neuronal survival in various models of central nervous system (CNS) injury. Here, in an attempt to induce a neuroprotective microglial cell pheno...

journal_title：Experimental neurology

authors： Gowing G,Lalancette-Hébert M,Audet JN,Dequen F,Julien JP

更新日期：2009-12-01 00:00:00

abstract：:Inflammation plays a central role in the development of numerous disorders of the central nervous system (CNS) such as multiple sclerosis (MS). For a long time it was assumed that recruitment of macrophages into the CNS and breakdown of the blood-brain barrier (BBB) are closely linked. In the present study we challeng...

journal_title：Experimental neurology

authors： Ladewig G,Jestaedt L,Misselwitz B,Solymosi L,Toyka K,Bendszus M,Stoll G

更新日期：2009-11-01 00:00:00

abstract：:Amyotrophic lateral sclerosis [ALS] is a rapidly progressive neurodegenerative disorder of motor neurons, heralded by the development of cortical hyperexcitability. Reduction of short interval intracortical inhibition [SICI] in ALS, a feature linked to the development of cortical hyperexcitability, may be mediated by ...

journal_title：Experimental neurology

authors： Vucic S,Cheah BC,Kiernan MC

更新日期：2009-11-01 00:00:00

abstract：:Muscular dystrophies (MDs) consist of a genetically heterogeneous group of disorders, recessive or dominant, characterized by progressive skeletal muscle weakening. To date, no effective treatment is available. Experimental strategies pursuing muscle regeneration through the transplantation of stem cell preparations h...

journal_title：Experimental neurology

authors： Darabi R,Baik J,Clee M,Kyba M,Tupler R,Perlingeiro RC

更新日期：2009-11-01 00:00:00

abstract：:The abuse of pharmaceutical drugs and the inadequate ingestion of nutrients constitute external factors that can alter brain development, both individually and in combination. We used cortical spreading depression (CSD) as a neurophysiological parameter to investigate the combined effects of the antipyretic/analgesic/...

journal_title：Experimental neurology

authors： do Amaral AP,Barbosa MS,de Souza VC,Ramos IL,Guedes RC

更新日期：2009-10-01 00:00:00

abstract：:The transformation of a cut axonal end into a growth cone (GC), after axotomy, is a critical event in the cascade leading to regeneration. In an earlier series of studies we analyzed the cellular cascades that transform a cut axonal end into a competent GC. We found that axotomy of cultured Aplysia neurons leads to a ...

journal_title：Experimental neurology

authors： Kamber D,Erez H,Spira ME

更新日期：2009-09-01 00:00:00

abstract：:Dopamine (DA) affects GABA neuronal function in the striatum and together these neurotransmitters play a large role in locomotor function. We recently reported that unilateral striatal administration of GDNF, a growth factor that has neurotrophic effects on DA neurons and enhances DA release, bilaterally increased str...

journal_title：Experimental neurology

authors： Salvatore MF,Gerhardt GA,Dayton RD,Klein RL,Stanford JA

更新日期：2009-09-01 00:00:00

abstract：:Mutations of the PINK1 gene are a cause of autosomal recessive Parkinson's disease (PD). PINK1 encodes a mitochondrial kinase of unknown function which is widely expressed in both neuronal and non-neuronal cells. We have studied fibroblast cultures from four family members harbouring the homozygous p.Q456X mutation in...

journal_title：Experimental neurology

authors： Grünewald A,Gegg ME,Taanman JW,King RH,Kock N,Klein C,Schapira AH

更新日期：2009-09-01 00:00:00

abstract：:Given the profound negative public health effects of major depressive disorder (MDD), and data suggesting only modest effectiveness of existing psychological and pharmacological treatments for this condition, there has been increasing interest in exploring the antidepressant potential of non-pharmacological, brain-bas...

journal_title：Experimental neurology

authors： Giacobbe P,Mayberg HS,Lozano AM

更新日期：2009-09-01 00:00:00

abstract：:Mitochondria play a pivotal role in the cascade of events associated with cell death pathways that are involved with several forms of neurodegeneration. Recent findings show that in the Bax/Bak-dependent pathway of apoptosis, the release of cytochrome c from mitochondria is a consequence of two carefully coordinated e...

journal_title：Experimental neurology

authors： Perkins G,Bossy-Wetzel E,Ellisman MH

更新日期：2009-08-01 00:00:00

abstract：:We compared mitochondrial respiratory chain function, mitochondrial DNA (mtDNA) integrity, and oxidative stress levels in muscle, myoblasts, fibroblasts and cybrids, from 12 amyotrophic lateral sclerosis (ALS) patients with 28 control samples. Mitochondrial respiratory chain enzyme activities were normal in muscle, my...

journal_title：Experimental neurology

authors： Bradley LJ,Taanman JW,Kallis C,Orrell RW

更新日期：2009-07-01 00:00:00

abstract：:It is difficult to assess cerebral function in comatose patients. Because earlier functional neuroimaging studies demonstrate associations between cerebral metabolism and levels of consciousness, fMRI in comatose survivors of cardiac arrest could provide further insight into cerebral function during coma. Using fMRI, ...

journal_title：Experimental neurology

authors： Gofton TE,Chouinard PA,Young GB,Bihari F,Nicolle MW,Lee DH,Sharpe MD,Yen YF,Takahashi AM,Mirsattari SM

更新日期：2009-06-01 00:00:00

abstract：:An increasing body of research suggests that a number of immune mechanisms play a role in degenerative pathways in Parkinson's disease (PD). In the current work we investigated a posited humoral immune response in this disorder. Sera from PD patients exhibited a significantly enhanced absorbance response on a novel EL...

journal_title：Experimental neurology

authors： Double KL,Rowe DB,Carew-Jones FM,Hayes M,Chan DK,Blackie J,Corbett A,Joffe R,Fung VS,Morris J,Riederer P,Gerlach M,Halliday GM

更新日期：2009-06-01 00:00:00

abstract：:Several lines of evidence have demonstrated beneficial effects of the hematopoietic factor G-CSF in experimental stroke. A conclusive demonstration of this effect in G-CSF deficient mice is, however, lacking. We therefore investigated the effect of G-CSF deficiency on infarct volumes, functional recovery, mRNA and pro...

journal_title：Experimental neurology

authors： Sevimli S,Diederich K,Strecker JK,Schilling M,Klocke R,Nikol S,Kirsch F,Schneider A,Schäbitz WR

更新日期：2009-06-01 00:00:00

abstract：:Embryonic stem cells (ESCs) promise an unlimited source of defined cells for cell transplantation therapy, while protocols for derivation of homogeneous populations of desirable cell types are yet to be developed and/or refined. Gamma aminobutyric acid (GABA) is a major inhibitory neurotransmitter in the central nervo...

journal_title：Experimental neurology

authors： Chatzi C,Scott RH,Pu J,Lang B,Nakamoto C,McCaig CD,Shen S

更新日期：2009-06-01 00:00:00

abstract：:Nerve injury frequently results in development of chronic, dysesthetic pain and allodynia (painful sensation in response to benign stimulation). Following nerve injury, spinal cord glia become activated and secrete a number of inflammatory cytokines, including interleukin-1 (IL-1), which exists as two genetically dist...

journal_title：Experimental neurology

authors： Skoff AM,Zhao C,Adler JE

更新日期：2009-06-01 00:00:00

abstract：:beta-N-methylamino-l-alanine (BMAA) is a non-protein amino acid implicated in the neurodegenerative disease amyotrophic lateral sclerosis/Parkinson-dementia complex (ALS/PDC) on Guam. BMAA has recently been discovered in the brains of Alzheimer's patients in Canada and is produced by various species of cyanobacteria a...

journal_title：Experimental neurology

authors： Liu X,Rush T,Zapata J,Lobner D

更新日期：2009-06-01 00:00:00

abstract：:Cinnamophilin (CINN, (8R, 8'S)-4, 4'-dihydroxy-3, 3'-dimethoxy-7-oxo-8, 8'-neolignan) protects against ischemic stroke in mice. While some anti-oxidative effects of CINN have been characterized, its therapeutic window and molecular basis for neuroprotection remain unclear. We evaluated antioxidant and anti-inflammator...

journal_title：Experimental neurology

authors： Lee EJ,Chen HY,Hung YC,Chen TY,Lee MY,Yu SC,Chen YH,Chuang IC,Wu TS

更新日期：2009-05-01 00:00:00

abstract：:The success of peripheral nerve regeneration depends on intrinsic properties of neurons and a favorable environment, although the mechanisms underlying the molecular events during degeneration and regeneration are still not elucidated. Schwann cells are considered one of the best candidates to be closely involved in t...

journal_title：Experimental neurology

authors： Narciso MS,Mietto Bde S,Marques SA,Soares CP,Mermelstein Cdos S,El-Cheikh MC,Martinez AM

更新日期：2009-05-01 00:00:00

abstract：:Temporal lobe epilepsy (TLE) is often accompanied by granule cell dispersion (GCD), a migration defect of granule cells in the dentate gyrus. We have previously shown that a decrease in the expression of reelin, an extracellular matrix protein important for neuronal positioning, is associated with the development of G...

journal_title：Experimental neurology

authors： Müller MC,Osswald M,Tinnes S,Häussler U,Jacobi A,Förster E,Frotscher M,Haas CA

更新日期：2009-04-01 00:00:00

abstract：:Serial diffusion tensor imaging scans were collected at baseline and 1 year follow-up to investigate the neurodegenerative profile of white matter (WM) in seven individuals with the Huntington's Disease (HD) gene mutation and seven control subjects matched on age and gender. In the HD subjects, but not controls, a sig...

journal_title：Experimental neurology

authors： Weaver KE,Richards TL,Liang O,Laurino MY,Samii A,Aylward EH

更新日期：2009-04-01 00:00:00

abstract：:One of the sexual dimorphic differences in adult rodents is neural proliferation. Here we demonstrate that physiological hormone stages can modulate this proliferation in the adult forebrain. Female mice, both pregnant and synchronized in oestrus, exhibited higher proliferating cell percentages than males in both the ...

journal_title：Experimental neurology

authors： Díaz D,Valero J,Airado C,Baltanás FC,Weruaga E,Alonso JR

更新日期：2009-04-01 00:00:00

abstract：:RNA interference appears to have a great potential not only as an in vitro target validation, but also as a novel therapeutic strategy based on the highly specific and efficient silencing of a target gene. We hypothesize that MMP-9 siRNA can be effective as an MMP-9 protein inhibitor in a rat focal ischemia model. Mal...

journal_title：Experimental neurology

authors： Hu Q,Chen C,Yan J,Yang X,Shi X,Zhao J,Lei J,Yang L,Wang K,Chen L,Huang H,Han J,Zhang JH,Zhou C

更新日期：2009-03-01 00:00:00

abstract：:Huntington's disease is an autosomal dominant neurogenetic disorder leading to striatal atrophy, characterized by involuntary movements. Voluntary movements also deteriorate, but the neurophysiological mechanisms are less understood. We investigated voluntary movement execution and its neural correlates by means of mo...

journal_title：Experimental neurology

authors： Beste C,Konrad C,Saft C,Ukas T,Andrich J,Pfleiderer B,Hausmann M,Falkenstein M

更新日期：2009-03-01 00:00:00

abstract：:Secondary degeneration is a form of 'bystander' damage that can affect neural tissue both nearby and remote from an initial injury. Partial optic nerve transection is an excellent model in which to unequivocally differentiate events occurring during secondary degeneration from those resulting from primary CNS injury. ...

journal_title：Experimental neurology

authors： Fitzgerald M,Bartlett CA,Evill L,Rodger J,Harvey AR,Dunlop SA

更新日期：2009-03-01 00:00:00

abstract：:Activation of N-methyl-d-aspartate (NMDA) receptors in the spinal dorsal horn has been shown to be essential for the initiation of central sensitization and the hyperexcitability of dorsal horn neurons in chronic pain. However, whether the spinal NR2B-containing NMDA (NMDA-2B) receptors are involved still remains larg...

journal_title：Experimental neurology

authors： Qu XX,Cai J,Li MJ,Chi YN,Liao FF,Liu FY,Wan Y,Han JS,Xing GG

更新日期：2009-02-01 00:00:00

abstract：:A prospective, multicenter, randomized trial did not demonstrate improved outcomes in severe traumatic brain injured patients treated with mild hypothermia [Clifton, G.L., Miller, E.R., Choi, S.C., Levin, H.S., McCauley, S., Smith, K.R., Jr., Muizelaar, J.P., Wagner, F.C., Jr., Marion, D.W., Luerssen, T.G., Chesnut, R...

journal_title：Experimental neurology

authors： Ma M,Matthews BT,Lampe JW,Meaney DF,Shofer FS,Neumar RW

更新日期：2009-01-01 00:00:00

abstract：:The ventrolateral orbital cortex (VLO) is part of an endogenous analgesic system consisting of an ascending pathway from the spinal cord to VLO via the thalamic nucleus submedius (Sm) and a descending pathway to the spinal cord relaying in the periaqueductal gray (PAG). This study examines whether activation of D(1)-l...

journal_title：Experimental neurology

authors： Sheng HY,Qu CL,Huo FQ,Du JQ,Tang JS

更新日期：2009-01-01 00:00:00

abstract：:Recent evidence indicates that protein aggregation and in particular the formation of toxic protein oligomers is a key mechanism in synucleinopathies such as Parkinson's disease (PD). Post mortem brain tissue studies as well as animal studies furthermore suggest that matrix metalloproteinases (MMPs) are also involved ...

journal_title：Experimental neurology

authors： Levin J,Giese A,Boetzel K,Israel L,Högen T,Nübling G,Kretzschmar H,Lorenzl S

更新日期：2009-01-01 00:00:00

abstract：:The effects of a very low oral dose of Al on spatial learning and neurogenesis were evaluated in a transgenic mouse (Tg 2576) model of Alzheimer disease. At 5 months of age, wild and Tg 2576 mice received a diet supplemented with Al lactate at 0 and 1 mg/g of diet for 120 days. The experimental groups (n=7-8) were: co...

journal_title：Experimental neurology

authors： Ribes D,Colomina MT,Vicens P,Domingo JL

更新日期：2008-12-01 00:00:00

abstract：:Several mutations in transthyretin (TTR) are related to familial amyloidotic polyneuropathy (FAP), a neurodegenerative disorder caused by extracellular deposition of TTR fibrils, particularly in the peripheral nervous system (PNS). TTR is mainly synthesized by the liver and choroid plexus of the brain that contribute ...

journal_title：Experimental neurology

authors： Sousa MM,Saraiva MJ

更新日期：2008-12-01 00:00:00

abstract：:We report on a 41-year old woman with prolonged comatose unresponsiveness following traumatic head injury. Structural MRI showed bilateral midbrain damage and ventriculomegalia. Functional MRI revealed robust cortical responses to visual, auditory and tactile stimulation. Speech stimuli moreover consistently elicited ...

journal_title：Experimental neurology

authors： Eickhoff SB,Dafotakis M,Grefkes C,Stöcker T,Shah NJ,Schnitzler A,Zilles K,Siebler M

更新日期：2008-12-01 00:00:00

abstract：:The study investigates if alpha-lipoic acid is neuroprotective against chemotherapy induced neurotoxicity, if mitochondrial damage plays a critical role in toxic neurodegenerative cascade, and if neuroprotective effects of alpha-lipoic acid depend on mitochondria protection. We used an in vitro model of chemotherapy i...

journal_title：Experimental neurology

authors： Melli G,Taiana M,Camozzi F,Triolo D,Podini P,Quattrini A,Taroni F,Lauria G

更新日期：2008-12-01 00:00:00

abstract：:A "neuroplastic" hypothesis proposes that changes in neuronal structural plasticity may underlie the aetiology of depression and the action of antidepressants. The medial prefrontal cortex (mPFC) is affected by this disorder and shows an intense expression of the polysialylated form of the neural cell adhesion molecul...

journal_title：Experimental neurology

authors： Castillo-Gómez E,Gómez-Climent MA,Varea E,Guirado R,Blasco-Ibáñez JM,Crespo C,Martínez-Guijarro FJ,Nácher J

更新日期：2008-11-01 00:00:00

abstract：:AMPAkines are positive modulators of AMPA receptors, and previous work has shown that these compounds can facilitate synaptic plasticity and improve learning and memory in both animals and humans; thus, their role in the treatment of cognitive impairment is worthy of investigation. In this study, we have utilized an o...

journal_title：Experimental neurology

authors： Kanju PM,Parameshwaran K,Sims C,Bahr BA,Shonesy BC,Suppiramaniam V

更新日期：2008-11-01 00:00:00

abstract：:Hyperreflexia develops after spinal cord injury (SCI) in the human and in the spinal cord transected animal, and can be measured by the loss of low frequency-dependent depression of the H-reflex. Previous studies demonstrated normalization of low frequency-dependent depression of the H-reflex using passive exercise wh...

journal_title：Experimental neurology

authors： Yates CC,Charlesworth A,Reese NB,Skinner RD,Garcia-Rill E

更新日期：2008-10-01 00:00:00

abstract：:Alzheimer's disease is associated with an age-related accumulation of Abeta and inflammation. The inflammatory mediator, TNFalpha activates a signaling cascade involving NFkappaB translocation to the nucleus and a beneficial or detrimental transcriptional response, depending on the age of the neurons and the type of s...

journal_title：Experimental neurology

authors： Patel JR,Brewer GJ

更新日期：2008-09-01 00:00:00

abstract：:Successful clinical application of fMRI tasks requires reliable knowledge about the brain structures mapped by the task. With memory fMRI, diverging evidence exists concerning the location of major signal sources as well as hippocampal contributions. To clarify these issues, we investigated a frequently applied memory...

journal_title：Experimental neurology

authors： Beisteiner R,Drabeck K,Foki T,Geissler A,Gartus A,Lehner-Baumgartner E,Baumgartner C

更新日期：2008-09-01 00:00:00

abstract：:Alpha-tyrosinated tubulin is a cytoskeletal protein that is involved in axonal growth and is considered a marker of neuronal plasticity in adult mammals. In adult rats, unilateral ablation of the left facial sensorimotor cortical areas induces degeneration of corticotrigeminal projections and marked denervation of the...

journal_title：Experimental neurology

authors： De Riu PL,Russo A,Pellitteri R,Stanzani S,Tringali G,Roccazzello AM,De Riu G,Marongiu P,Mameli O

更新日期：2008-09-01 00:00:00